Stanford
Wang Lab at Stanford Ophthalmology

Publications

1.  Lin, C.-H., Wu, M.-R., Tanasa, B., Prakhar, P., Deng, B., Davis, A. E., Li, L., Xia, A., Shan, Y., Fort, P. E., and Wang, S. (2024) Induction of a Müller glial cell-specific protective pathway safeguards the retina from diabetes induced damage. Diabetes. 10.2337/db24-0199. PMID: 39446557

2. Wang, Q., Xu, X., Chen, S., Lu, R., Li, L., Lo, C.H., Liu, Z., Ning, K., Li, T.,4, Kowal, T.J., Wang, B., Hartnett, M.E., Wang, S., Qi, L.S., Sun, Y. (2024) dCasMINI-Mediated Therapy Rescues Photoreceptors Degeneration in a Mouse Model of Retinitis Pigmentosa. Science Advances. In press.

3. Liu, Z., Chen, S., Davis, A.E., Lo, C.H., Wang, Q., Li, T., Ning, K., Zhang, Q., Zhao, J., Wang, S., Sun, Y. (2024) Efficient Rescue of Retinal Degeneration in Pde6a Mice by Engineered Base Editing and Prime Editing. Advanced Science. Nov;11(42):e2405628. doi: 10.1002/advs.202405628. Epub 2024 Sep 19. PMCID: PMC11558111

4. Xie, Z., Zhang, T., Kim, S., Lu, J., Zhang, W., Lin, C.-H., Wu, M.-R., Davis, A., Channa, R., Giancardo, L., Chen, H., Wang, S., Chen, R., and Zhi, D. (2024) iGWAS: Image-based genome-wide association of self-supervised deep phenotyping of retina fundus images. PLOS Genetics. 20, e1011273. 

5. Acarón Ledesma, H., Ding, J., Oosterboer, S., Huang, X., Chen, Q., Wang, S., Lin, M. Z., and Wei, W. (2024) Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells. Nature Communication. 15, 1819. 

6. Kim, G., Chen, Z., Li, J., Luo, J., Castro-Martinez, F., Wisniewski, J., Cui, K., Wang, Y., Sun, J., Ren, X., Crawford, S. E., Becerra, S. P., Zhu, J., Liu, T., Wang, S., Zhao, K., and Wu, C. (2024) Gut-liver axis calibrates intestinal stem cell fitness. Cell. 187, 914-930.e20. 

7. Liu, L., Jiang, Y., Al-Shabrawey, M., Ren, X., Wang, S., and Steinle, J. J. (2024) EphB1 causes retinal damage through inflammatory pathways in the retina and retinal Müller cells. Molecular Vision. 30, 167–174.

8. Evans SW, Shi DQ, Chavarha M, … Wang, S, Clandinin TR, Dror RO, Ding JB, Ji N, Golshani P, Giocomo LM, Bi GQ, Lin MZ. (2023). A positively tuned voltage indicator for extended electrical recordings in the brain. Nature Methods 20, 1104–1113. 10.1038/s41592-023-01913-z.

9. Albarran, E., Sun, Y., Liu, Y., Raju, K., Dong, A., Li, Y., Wang, S., Südhof, T.C., and Ding, J.B. (2023). Postsynaptic synucleins mediate endocannabinoid signaling. Nature Neuroscience 26, 997–1007. 10.1038/s41593-023-01345-0.

10. Li, L., Sun, Y., Davis, A.E., Shah, S.H., Hamed, L.K., Wu, M.-R., Lin, C.-H., Ding, J.B., and Wang, S. (2023). Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells. Cell Reports 42, 112596. 10.1016/j.celrep.2023.112596.

11. Guo, L.Y., Bian, J., Davis, A.E., Liu, P., Kempton, H.R., Zhang, X., Chemparathy, A., Gu, B., Lin, X., Rane, D.A., Xu, X., Jamiolkowski, R.M., Hu, Y., Wang, S.*, Qi, L.S.*. (2022). Multiplexed genome regulation in vivo with hyper-efficient Cas12a. Nature Cell Biol, 1–11. 10.1038/s41556-022-00870-7.

12. Lin, C.-H., Sun, Y.J., Lee, S.H., Mujica, E.M., Kunchur, C.R., Wu, M.-R., Yang, J., Jung, Y.S., Chiang, B., Wang, S*, Mahajan, V.B*., et al. (2022). A protocol to inject ocular drug implants into mouse eyes. STAR Protocols, 3, 101143. 10.1016/j.xpro.2022.101143.

13. Lin, C.-H., Sun, Y., Chan, C.S.Y., Wu, M.-R., Gu, L., Davis, A.E., Gu, B., Zhang, W., Tanasa, B., Zhong, L.R., Emerson, M.M., Chen, L., Ding, J.B., Wang, S. (2022). Identification of cis-regulatory modules for adeno-associated virus-based cell-type-specific targeting in the retina and brain. Journal of Biological Chemistry 298. https://doi.org/10.1016/j.jbc.2022.101674

14. Sun, Y.J., Lin, C.-H., Wu, M.-R., Lee, S.H., Yang, J., Kunchur, C.R., Mujica, E.M., Chiang, B., Jung, Y.S., Wang, S.*, Mahajan, V.B.* (2021). An intravitreal implant injection method for sustained drug delivery into mouse eyes. Cell Reports Methods, https://doi.org/10.1016/j.crmeth.2021.100125.

15. Chen, Z., Luo, J., Li, J., Kim, G., Chen, E.S., Xiao, S., Snapper, S.B., Bao, B., An, D., Blumberg, R.S., Lin, C., Wang, S., Zhong, J., Liu, K., Li, Q., Wu, C., Kuchroo, V.K. (2021). Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion. Journal of Experimental Medicine 218, e20210324. https://doi.org/10.1084/jem.20210324

16. Chan, C.S.Y., Lonfat, N., Zhao, R., Davis, A.E., Li, L., Wu, M.-R., Lin, C.-H., Ji, Z., Cepko, C.L., Wang, S. (2020). Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina. Development 147. https://doi.org/10.1242/dev.187922 

17. Liu, J., Banerjee, A., Herring, C.A., Attalla, J., Hu, R., Xu, Y., Shao, Q., Simmons, A.J., Dadi, P.K., Wang, S., Jacobson, D.A., Liu, B., Hodges, E., Lau, K.S., Gu, G. (2019). Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Dev. Cell 48, 49-63.e7. https://doi.org/10.1016/j.devcel.2018.11.048

18. Maeder, C.I., Kim, J.-I., Liang, X., Kaganovsky, K., Shen, A., Li, Q., Li, Z., Wang, S., Xu, X.Z.S., Li, J.B., Xiang, Y.K., Ding, J.B., Shen, K. (2018). The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 1436-1449.e20. https://doi.org/10.1016/j.cell.2018.07.046

19. Huang, C., Walker, E.M., Dadi, P.K., Hu, R., Xu, Y., Zhang, W., Sanavia, T., Mun, J., Liu, J., Nair, G.G., Tan, H.Y.A., Wang, S., Magnuson, M.A., Stoeckert, C.J., Hebrok, M., Gannon, M., Han, W., Stein, R., Jacobson, D.A., Gu, G. (2018). Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev. Cell 45, 347-361.e5. https://doi.org/10.1016/j.devcel.2018.03.01

20. Lin, S., Nascimento, E.M., Gajera, C.R., Chen, L., Neuhöfer, P., Garbuzov, A., Wang, S., Artandi, S.E. (2018). Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature 556, 244–248. https://doi.org/10.1038/s41586-018-0004-7

21. Tang, J.C., Drokhlyansky, E., Etemad, B., Rudolph, S., Guo, B., Wang, S., Ellis, E.G., Li, J.Z., Cepko, C.L. (2016). Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. eLife 5, e15312. https://doi.org/10.7554/eLife.15312

22. Wang, S., Cepko, C.L. (2016). Photoreceptor Fate Determination in the Vertebrate Retina. Invest. Ophthalmol. Vis. Sci. 57, ORSFe1-6. https://doi.org/10.1167/iovs.15-17672

23. Wang, S., Sengel, C., Emerson, M.M., Cepko, C.L. (2014) A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina. Dev. Cell, 30, 513–527. https://doi.org/10.1016/j.devcel.2014.07.018

24. Cherry, T.J., Wang, S., Bormuth, I., Schwab, M., Olson, J., Cepko, C.L. (2011). NeuroD factors regulate cell fate and neurite stratification in the developing retina. J. Neurosci. 31, 7365–7379. https://doi.org/10.1523/JNEUROSCI.2555-10.2011

25. Wang, S., Yan, J., Anderson, D.A., Xu, Y., Kanal, M.C., Cao, Z., Wright, C.V.E., Gu, G. (2010). Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol 339, 26–37. https://doi.org/10.1016/j.ydbio.2009.12.009

26. Wang, S., Jensen, J.N., Seymour, P.A., Hsu, W., Dor, Y., Sander, M., Magnuson, M.A., Serup, P., Gu, G. (2009). Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. PNAS 106, 9715–9720. https://doi.org/10.1073/pnas.0904247106

27. Wang, S., Hecksher-Sorensen, J., Xu, Y., Zhao, A., Dor, Y., Rosenberg, L., Serup, P., Gu, G. (2008). Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol 317, 531–540. https://doi.org/10.1016/j.ydbio.2008.02.052

28. Wang, S., Zhang, J., Zhao, A., Hipkens, S., Magnuson, M.A., Gu, G. (2007). Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech. Dev. 124, 898–910. https://doi.org/10.1016/j.mod.2007.08.004

29. Xu, Y., Wang, S., Zhang, J., Zhao, A., Stanger, B.Z., Gu, G. (2006). The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3. Dev Biol 297, 340–349. https://doi.org/10.1016/j.ydbio.2006.04.456